Myocardial Hypertrophic Preconditioning Attenuates Cardiomyocyte Hypertrophy and Slows Progression to Heart Failure Through Upregulation of S100A8/A9 Running title: Wei et al.; Role of hypertrophic preconditioning
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چکیده
So So Sou ut uthe hern n M M Me edic ical al U Uni nive ers rsity, y, G Gua ang ngzhou o , , Ch hin ina a a; 2 Card rdio iovascul ul ula a ar D Div ivis ision, n, D Dep pt of f M Med e icine, Na Na Nati t o on onal al al C C Ce er ereb eb bra ra al l a an and d Ca a ard d diov va vas scul ul la ar ar C C Cen n nte ter r r, O O Osa saka k k , Ja Japa pa pan n *c c con ont t trib b but ute ed ed e eq qu qua al ally ly y Address for r r Co Co Corr rr rres es spo po pond nd n en en ence c ce: Abstract Background—Transient preceding brief ischemia provides potent cardioprotection against
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Myocardial Hypertrophic Preconditioning Attenuates Cardiomyocyte Hypertrophy and Slows Progression to Heart Failure Through Upregulation of S100A8/A9
BACKGROUND Transient preceding brief ischemia provides potent cardioprotection against subsequent long ischemia, termed ischemic preconditioning. Here, we hypothesized that transient short-term hypertrophic stimulation would induce the expression of hypertrophy regression genes and render the heart resistant to subsequent hypertrophic stress, and slow the progression to heart failure, as well. ...
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